3D-hUMSCs exosomes enriched with miR-125b-5p and miR-132-3p ameliorate vitiligo by simultaneously suppressing oxidative stress-induced melanocyte damage and potentiating Treg cells-mediated immunosuppression

As a crucial component of exosome cargo, miRNAs have been reported to be deeply involved in regulating intercellular communication and multiple biological functions. Based on the results above, we performed high-throughput miRNA sequencing of 2D-Exo and 3D-Exo to identify the potential miRNAs. Overall design: Exosomes extracted from 2D and 3D cultured human umbilical cord mesenchymal stem cells supernatants were sequenced