Tab1

ENCODES a protein that exhibits MAP kinase kinase kinase activity; mitogen-activated protein kinase p38 binding; protein-containing complex binding; INVOLVED IN positive regulation of MAP kinase activity; aorta development (ortholog); cardiac septum development (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; interleukin-1 signaling pathway; nuclear factor kappa B signaling pathway; ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); polycystic ovary syndrome (ortholog); Rubinstein-Taybi syndrome (ortholog); FOUND IN protein-containing complex; cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil

编码一种表现出MAP激酶激酶激酶活性的蛋白质；参与细胞因子激活蛋白激酶p38的结合；蛋白复合物结合；涉及MAP激酶活性的正向调控；主动脉发育（同源）；心室间隔发育（同源）；参与骨形态发生蛋白信号通路；白细胞介素-1信号通路；核因子κB信号通路；与腺苷琥珀酸裂解酶缺乏症（同源）相关；多囊卵巢综合征（同源）；Rubinstein-Taybi综合征（同源）；存在于蛋白复合物中；细胞质（同源）；细胞溶质（同源）；与（S）-尼古丁、2,3,7,8-四氯二苯并-对二噁英、6-丙基-2-硫尿嘧啶相互作用。