IC<sub>50</sub> values for small molecule inhibitors of TGF–β1 signaling.

NIAID Data Ecosystem2026-03-10 收录

数据链接：

https://figshare.com/articles/dataset/IC_sub_50_sub_values_for_small_molecule_inhibitors_of_TGF_1_signaling_/7395782 数据链接链接失效反馈

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资源简介：

IC50 values for small molecule inhibitors of TGF–β1 signaling.

创建时间：

2018-11-28

Galunisertib (LY2157299), a transforming growth factor-β receptor I kinase inhibitor, attenuates acute pancreatitis in rats

急性胰腺炎

TGF-β信号通路调控

Galunisertib (LY2157299), a selective ATP-mimetic inhibitor of TGF-β receptor I (TGF-βRI), is the only known TGF-β pathway inhibitor. In the present study, we investigated the effect of galunisertib o

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Biological activity of 5-(thiophen-2-yl)pyrimidine derivatives with diversification at the 4-position of the thiophene core.

药物活性筛选

构效关系

aSee footnote of Table 2.

NIAID Data Ecosystem50

石杉碱甲二聚体体外生物活性检测报告、原始数据、原始图片

药物活性筛选

抗炎

石杉碱甲二聚体体外生物活性评价包括，检测石杉碱甲二聚体乙酰胆碱脂酶抑制（AChEIs）效率，如IC50，并通过体外构建人关节炎软骨细胞2D 培养模型，检测软骨细胞内及上清液中炎症因子（如TNF-ɑ, INOS, MMP-13, IL-6）水平及AChE mRNA表达及活性水平，明确石杉碱甲二聚体的抗炎作用；同时，还检测了不同烟碱受体（CHRNA4, CHRNA6, CHRNA7, CHRNB4,

国家人口健康科学数据中心40

Study of three-dimensional structure of chromatin through a 4C-seq experiment in mouse NSC shControl and shJMJD3 upon TGFβ treatment [Chst8]

染色质三维构象分析

TGF-β信号通路调控

In this study we analyzed how multiple enhancers arrange in the 3D-space to control the activation of a specific promoter. Specifically, we did a 4C-seq experiment on a ~374 Kb locus where enhancers a

NIAID Data Ecosystem70

Expression data from TGF-beta-treated human ovarian fibroblasts

癌微环境

TGF-β信号通路调控

Advanced ovarian cancer is the most lethal gynecologic malignancy in the United States. Ovarian cancer cells are known to have diminished response to TGF-beta, but it remains unclear whether TGF-beta

NIAID Data Ecosystem40

IC<sub>50</sub> values for small molecule inhibitors of TGF–β1 signaling.

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