This data contains fitness values for PPAT protein mutants described in:Plesa C, Sidore AM, Lubock N, Zhang D, Kosuri S. Multiplexed Gene Synthesis in Emulsions for Exploring Protein Functional Landsc

Figshare2018-03-15 更新50

Deep mutational scanning of NDM-1 metallo-beta-lactamase

细菌耐药性机制

蛋白质功能突变

The NDM-1 metallo-beta-lactamase (MBL) was mutated to all single amino acid mutants, then placed under selection with 3 antibiotics (ampicillin, cefotaxime, meropenem) to characterize the mutants' fun

NIAID Data Ecosystem30

Mutated residues of FBPase and the effect of mutations on allosteric inhibition and enzyme activity.

酶变构调控

蛋白质功能突变

Underlined characters represent mutated amino acids that led to the elimination of allosteric regulation without loss of enzyme activity. Residues with conservation scores<0.5 are highlighted with bol

NIAID Data Ecosystem50

Specificity constants for human wild-type and nucleotide-binding mutant c-NADP-ME variants.

动力学分析

蛋白质功能突变

Specificity constants for human wild-type and nucleotide-binding mutant c-NADP-ME variants.

Figshare2015-12-02 更新30