First observation of a mutation (L26F) in a weak D phenotype encoded by 76 C>T, ethnic origin: Austria. undefined

Sanger sequencing of RHD exons 1 to 10 and boundaries elucidated a novel C>T alteration at position 76 causing for a L26F amino acid alteration. According to the transmembraneous position of the alteration and an RhD antigen density of approximately 4.800 epitopes/cell, this allele enlarges the number of RHD weak D alterations.