PPARG- and EGR1-directed anti-fibrotic miRNA network regulates cancer-associated liver fibrosis

To investigate contributions of miRNAs to hepatocellular carcinoma formation, we performed small RNA-seq analysis (sRNA-seq) of nodular and tumour samples derived from livers of mice overexpressing constitutively active variant of Serum Response Factor, SRF-VP16 and corresponding controls. As SRF-VP16-driven HCCs share several characteristics with human HCC , such as overlapping features of the tumour microenvironment in this study we have focus on investigation of the role of miRNAs in regulating HCC-associated fibrosis. We identified a miRNA network that regulates different structural, signalling and remodelling components of the ECM.