Defining the intestinal eCBome and oxylipin signaling systems in a TDP-43 mouse model of frontotemporal dementia

Frontotemporal dementia (FTD) is a group of early onset and progressive disorders, characterized by degeneration in the frontal and temporal lobes, and subsequent deterioration in cognition, personality, social behavior and language, with aggregates of the RNA-binding protein TDP-43 being present in ~45% of the cases. We reported alterations of the endocannabinoidome (eCBome) in the spinal cord of a TDP-43 mouse model of FTD. Here we investigated the small intestinal eCBome, oxylipins and, preliminarily, the gut microbiome. The duodenum, jejenum and ileum of TDP-43 forebrain overexpressing vs. wildtype mice were investigated. Intestinal content microbiota composition and fecal were studied by 16S DNA sequencing