five

ERK2-dependent gene expression

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE124947
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ERK is a key coordinator of the epithelial to mesenchymal transition (EMT). However, the mechanisms by which ERK controls the EMT program are not well understood. We used microarray to determine global changes of gene expression mediated by ERK2. Vector control, D319N ERK2, and Y261A ERK2 expression was induced by doxycycline in Tet-on MCF10A cell systems. Cells were grown for 7 days, and RNAs were purified from three individual replicates of each condition and microarray was performed.
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2019-04-12
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