IRF8 REGULATES EXPRESSION OF ANTIGEN PROCESSING AND PRESENTATION PATHWAYS IN MYELOID CELLS

ChEBI2011-04-27 更新2026-07-21 收录

抗原呈递调控

髓系细胞免疫学

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MEXP-2962 数据链接链接失效反馈

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资源简介：

IRF8 REGULATES EXPRESSION OF ANTIGEN PROCESSING AND PRESENTATION PATHWAYS IN MYELOID CELLS

创建时间：

2011-04-27

Mouse pancreas cell CRISPR screen targeting TSGs for total HLA and SIINFEKL presentation plus/minus interferon gamma. Mouse pancreas cell CRISPR screen targeting TSGs for total HLA and SIINFEKL presentation plus/minus interferon gamma

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CRISPRi筛选

C57BL/6 mouse pancreas cells were infected with a CRISPR library targeting TSGs. Total HLA and SIINFEKL presentation was measured by flow and cells were sorted for sequencing

NIAID Data Ecosystem80

Genetic ablation of ifitm1 and ifitm3 attenuates IFN- mediated induction of ISG15 and MHC class I molecules

干扰素信号通路

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Interferon-induced transmembrane protein (IFITM1) plays a dual role in restriction of RNA viruses and in metastatic cancer cell growth. The signal transduction events that are orchestrated by IFITM1 a

NIAID Data Ecosystem30

Summary of fold increase in CD8 T cell recognition of EBV-antigens presented by shBGLF5-LCLs compared to shControl-LCLs.

EBV抗原特异性CD8T细胞应答

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* more than one effector clone specific for each epitope was used where possible. In total, six different donor LCLs were used.

NIAID Data Ecosystem20

Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas [DLBCL_RNAseq]

肿瘤免疫逃逸

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Tumors frequently subvert MHC class I (MHC-I) peptide presentation to evade CD8+ T cell immunosurveillance, though how this is accomplished is not always well-defined. To identify the global regulator

NIAID Data Ecosystem70

Summary of fold increase in CD8 T cell recognition of EBV-antigens presented by shBILF1-LCLs compared to shControl-LCLs.

EBV免疫反应

抗原呈递调控

* more than one effector clone specific for each epitope was used where possible. In total, six different donor LCLs were used.

NIAID Data Ecosystem20