Crystal Structure of the bromodomain of human BRD9 in complex with the inhibitor Y22076

Crystal Structure of the bromodomain of human BRD9 in complex with the inhibitor Y22076 Descriptor: 1-[1-[4-(imidazol-1-ylmethyl)-3,5-dimethoxy-phenyl]indolizin-3-yl]ethanone, Bromodomain-containing protein 9, DIMETHYL SULFOXIDE Authors: Chen, Z, Zhang, C, Xu, H, Wu, X, Zhang, Y, Xu, Y. Deposit date: 2025-01-16 Release date: 2025-11-19 Last modified: 2026-01-14 Method: X-RAY DIFFRACTION (2.68 Å) Cite: Key imidazolyl groups that induce phenylalanine flipping enhance the efficacy of oral BRD9 inhibitors for AML treatment. Acta Pharm Sin B, 15, 2025