PtpA dephosphorylates GSK3A

Mtb infection inhibits the cleavage of inactive caspase-3 into its active forms by dephosphorylation of human glycogen synthase kinase-3 alpha (GSK3α). Tyr-279 is essential for the full activity of GSK3α. Mtb protein tyrosine phosphatase (PtpA) dephosphorylates Tyr-279 and thereby inactivates GSK3α (Poirier et al. 2014).

结核分枝杆菌感染通过去磷酸化人类糖原合成酶激酶-3α（GSK3α）来抑制其无活性形式裂解为其活性形式。Tyr-279对于GSK3α的完全活性至关重要。结核分枝杆菌蛋白酪氨酸磷酸酶（PtpA）去磷酸化Tyr-279，从而失活GSK3α（Poirier等，2014年）。