Host Polymorphs and Crystalline Host–Guest Complexes of 3,3′-Bis(9-hydroxy-9-fluorenyl)biphenyl

The diol host compound 2 featuring a structure with
two 9-fluorenol moieties attached in 3,3′-position to a biphenyl
core unit has been synthesized and is shown to form crystalline inclusion
complexes with organic guest molecules. Aside from the single-crystal
X-ray structures of unsolvated 2 in two polymorphous
forms (2A, 2B), structures of five inclusion
compounds with 1,4-dioxane (2a), DMSO (2b), diethylamine (2c), acetic acid (2d),
and ethyl acetate (2e) are described and comparatively
discussed in the interaction behavior including corresponding host
compounds with different attachment mode of the biphenyl unit and
the diphenylhydroxymethyl-substituted equivalent.

本研究成功合成了一种二噁哌主客体化合物2，该化合物结构中包含两个连接在3,3'-位点的9-荧光醇基团，并与联苯核心单元相结合。该化合物与有机客体分子形成晶体包合复合物的能力得到了证实。除了无溶剂状态下化合物2在两种同质异形体（2A、2B）中的单晶X射线结构外，还描述并比较讨论了与1,4-二氧六环（2a）、二甲基亚砜（2b）、二乙胺（2c）、乙酸（2d）和乙酸乙酯（2e）形成的五种包合物的结构，并探讨了这些包合物在相互作用行为中的特点，包括不同连接方式的联苯单元及其对苯二酚甲基取代等价物的对应主客体化合物。