In silico predictions for pathogenicity of the variants presented in this study.

Each predictor yields its own type of results, usually quantitative and categorical. We have chosen the most representative of each.1Predictors PON-P and Condel integrate results from other predictors run in their own servers; as PolyPhen-2 versions and their results differ if they are run in the PolyPhen-2 website or the other 2, all of them are shown for comparison. 2Classification of variants in different classes according to Align-GVGD algorithm (Align-Grantham Variation Grantham Deviation; http://agvgd.iarc.fr), C65 means “Most likely to interfere with function, C0 means “least likely” (possible classes are: C65> C55>C45>C35>C25>C15>C0).Abbreviations: Prob.-Probability; Pred.-Prediction; Funct.-Functional; Accur.-Accuracy; ΔΔG–ΔΔG value (kcal/mol); Del-Deleterious; N-Neutral; Dest- Destabilizing; P-Pathogenic; UV-Unknown Variant.