Antibiotic exposure is associated with minimal gut microbiome perturbations in healthy term infants

This is a prospective longitudinal birth cohort of n=323 healthy term African American children to determine the association between antibiotic exposure and the gut microbiome through shotgun metagenomics sequencing as well as bile acid pofiles through liquid chromatography-mass spectrometry. Stool samples were collected at ages 4, 12, and 24 months for antibiotic exposed (n=170) and unexposed (n=153) participants. A short-term substudy (n=39) collected stool samples at first exposure, and over 3 weeks following antibiotics initiation.