code for manuscript

Figshare2024-07-27 更新2026-04-28 收录

CAR-T细胞工程

白血病免疫治疗

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code for Ferritin aggregation: A neotype and universal engager for CAR T cell avidity engineering against diverse refractory leukemias

创建时间：

2024-07-27

Clonal expansion of CD8+ T cells reflects graft-versus-leukemia activity and precedes durable remission following DLI.

白血病免疫治疗

细胞克隆扩增

We show that an effective GvL is associated with a substantial drop of CD8+ TRB diversity and a concomitant expansion of dominant clones. TRB sequencing of sorted CD8+ T cells comparing leukemia patie

NIAID Data Ecosystem70

Framework humanization increases the affinity and potency of anti-CD72 nanobody-based CAR-T cells for B-cell malignancies. Framework humanization increases the affinity and potency of anti-CD72 nanobody-based CAR-T cells for B-cell malignancies

CAR-T细胞工程

B细胞恶性肿瘤免疫

Anti-CD19 CAR T cells can induce remissions in some patients with B-cell malignancies. However, new immunotherapeutic targets are urgently needed for the many who relapse. We recently described CD72 a

NIAID Data Ecosystem50

Targeting Interleukin-2-Inducible T-cell Kinase (ITK) differentiates GVL and GVHD in allo-HSCT

移植物抗宿主病治疗

白血病免疫治疗

Allogeneic hematopoietic stem cell transplantation is a potentially curative procedure for many malignant diseases. Donor T cells prevent disease recurrence via graft-versus-leukemia (GVL) effect. D

NIAID Data Ecosystem50

Gene expression profile of SmarT-cells compared to control 1G CAR T cells

CAR-T细胞工程

免疫细胞转录组学

The objective of this experiment was to compare the transcriptional profile of T cells modified to express CAR, TBBR and 4/7 ICR (i.e. SmarT-cells) against control 1G CAR T cells expressing CD3z endod

NIAID Data Ecosystem60

Single-cell CML TKI stop

白血病免疫治疗

单细胞免疫组学

Update 2/26! We also have data related to dasatinib+IFN-a in CML (Huuhtanen et al., JCI) in a different Zenodo:https://zenodo.org/records/10947495https://www.jci.org/articles/view/152585______________

Zenodo2026-02-20 更新50

code for manuscript

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