It is known that obese adipose tissues are hypoxic and express hypoxia-inducible factor (HIF)-1α. Although some studies have shown that the expression of HIF-1α in adipocytes induces glucose intoleran
To study the development mechanisms of type 2 diabetes, we examined multi-tissues' expression profiles of outbred mice fed with a high-fat diet (HFD) or regular chow at week 1, 9, and 18 and performed
Previous epidemiological and laboratorial studies have demonstrated a close relationship between plasma manganese (Mn) levels and type 2 diabetes (T2D), however, the underlying mechanism remains undis
we collected 290 stool samples from a previous reported Chinese cohort , followed by shotgun metagenomics and metaproteomics analyses. Here, we characterized substantial alterations of the intestinal
Objective Glucolipotoxicity is a major pathophysiological mechanism in the development of insulin resistance and type 2 diabetes mellitus (T2D). We aimed to detect subtle changes in the circulating li
