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BRAF paradox breakers PLX8394 and PLX7904 comparison to BRAF inhibitor PLX4720 effect on BRAF V600Ε mutant colorectal adenocarcinoma cells

ChEBI2021-01-14 更新2026-07-12 收录

靶向药物研发

结直肠癌治疗

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-9014 数据链接链接失效反馈

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BRAF paradox breakers PLX8394 and PLX7904 comparison to BRAF inhibitor PLX4720 effect on BRAF V600Ε mutant colorectal adenocarcinoma cells

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创建时间：

2021-01-14

结直肠癌治疗

药物剂量优化

Interventions: On Day 1, patients treated with FOLFIRI therapy received a 2-hour intravenous infusion of CPT-11 (150 mg/m2) combined with 1-LV (200 mg/m2), followed by a rapid intravenous infusion of

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TNIK抑制剂开发

结直肠癌治疗

The Traf2- and Nck-interacting protein kinase (TNIK) is a downstream signal protein of the Wnt/β-catenin pathway and has been thought of as a potential target for the treatment of colorectal cancer (C

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Crystal structure of D1228V c-MET bound by compound 1.

蛋白质晶体学

靶向药物研发

Crystal structure of D1228V c-MET bound by compound 1. Descriptor: 3-[bis(fluoranyl)methyl]-~{N}-methyl-~{N}-[(1~{R})-8-methyl-5-(3-methyl-1~{H}-indazol-6-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]pyridin

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Identification of M4205 a highly selective inhibitor of cKIT mutations for unresectable metastatic or recurrent GIST

靶向药物研发

cKIT抑制剂

Identification of M4205 a highly selective inhibitor of cKIT mutations for unresectable metastatic or recurrent GIST Descriptor: 5-imidazo[1,2-a]pyridin-3-yl-~{N}-[(1~{R})-1-(6-pyrrolidin-1-ylpyridin-

Protein Data Bank Japan2024-02-07 更新60

Discovery of Natural Products Targeting NQO1 via an Approach Combining Network-Based Inference and Identification of Privileged Substructures

靶向药物研发

天然药物筛选

NAD(P)H:quinone oxidoreductase 1 (NQO1) has been shown to be a potential therapeutic target for various human diseases, such as cancer and neurodegenerative disorders. Recent advances in computation

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BRAF paradox breakers PLX8394 and PLX7904 comparison to BRAF inhibitor PLX4720 effect on BRAF V600Ε mutant colorectal adenocarcinoma cells

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