Anti-cancer activity, docking studies and characterization of indole tethered 1,3,4-oxadiazole hybrids

This data pertains to the prediction and contribution of substituents in the oxadiazole dataset towards its anticancer potential. A set of oxadiazoles (6a-l) linked with indole were produced by heating pure compounds 5a-l with an excess of acetic anhydride for a duration of 4-5 hours. The resulting compounds were analyzed using FTIR, 1HNMR, 13C NMR, and mass spectroscopy. The article included spectral data of the compounds, as seen in Figure 5-19. The anticancer properties of newly synthesized compounds 6a-l were displayed graphically in Fig.20. The indole and oxadiazole moieties were combined in the proposed scaffold, and additional structural alterations were introduced to investigate the impact of these changes on the anticancer activity against MDA MB 361 cancer cells. The findings are presented in this study.