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Integrative analysis of single cell genomics data by coupled nonnegative matrix factorizations (ATAC-Seq)

NIAID Data Ecosystem2026-05-26 收录

单细胞多组学

染色质可及性分析

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP150786 数据链接链接失效反馈

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资源简介：

415 scATAC-seq samples generated for the retinoic acid-induced mESC differenation at day 4. Overall design: We present a method(Coupled NMF) to cluster single cell chromatin accessibility data and single cell gene expression data simultaneously.

应用场景：

创建时间：

2018-09-19

单细胞多组学

神经科学

Most existing single-cell techniques can only make one type of molecular measurements. Although computational approaches have been developed to integrate single-cell datasets, their efficacy still nee

干细胞与再生医学数据中心2022-02-20 更新100

Chromatin accessibility profiling of adult C. elegans in response to heat hormesis regimen

染色质可及性分析

热适应机制

To understand the molecular basis of heat hormesis, we adapted a regimen in which C. elegans that had been cultured at 20Â°C were exposed to 30Â°C for 6 hours during early adulthood (referred to as 'p

NIAID Data Ecosystem00

Characterization of Transcriptome and Chromatin Interactome in Accessible Regions at Single-cell Resolution by scAIR

单细胞多组学

染色质空间结构

The increasing prevalence of single-cell technologies has brought significant advancements in the study of cellular heterogeneity. However, there is a lack of techniques that can simultaneously captur

NIAID Data Ecosystem00

Transcription factor TCF1 binds Rorgt and orchestrates a regulatory network that determines homeostatic Th17 cell state [ATAC-seq]. Transcription factor TCF1 binds Rorgt and orchestrates a regulatory network that determines homeostatic Th17 cell state [ATAC-seq]

Th17细胞调控

染色质可及性分析

CD4+ T helper 17 (Th17) cells encompass a spectrum of cell states including homeostatic cells that maintain physiological functions such as barrier integrity and pathogenic cells that drive autoimmune

NIAID Data Ecosystem00

Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancers [ATAC-seq]. Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancers [ATAC-seq]

造血表观遗传学

染色质可及性分析

The H3K9me3-specific histone methyltransferase SETDB1 is critical for proper regulation of developmental processes, but the underlying mechanisms are only partially understood. Here, we show that dele

NIAID Data Ecosystem00

Integrative analysis of single cell genomics data by coupled nonnegative matrix factorizations (ATAC-Seq)

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