Synthesis of Benzodiazepine β-Turn Mimetics by an Ugi 4CC/Staudinger/Aza-Wittig Sequence. Solving the Conformational Behavior of the Ugi 4CC Adducts
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5-Oxobenzo[e][1,4]diazepine-3-carboxamides were synthesized by sequential Ugi reaction−Staudinger/aza-Wittig cyclization. The pseudopeptidic backbone of the new benzodiazepine derivatives superimposed well with type I, I′, II, and II′ β-turn motifs. The intermediate Ugi adducts were characterized as two conformers of the enol form by the correlation between 1H NMR spectra and X-ray diffraction structures of model compounds.
创建时间：
2009-03-06
