Role of the histone methylase G9a in pancreatic carcinogenesis. Role of the histone methylase G9a in pancreatic carcinogenesis

Accumulating evidences propose the importance of epigenetic regulation in pancreatic carcinogenesis, but the mechanistic insights of a variety of histone modification process still remains to be elucidated. G9a functions as a transcriptional repressor via the methylating activity specific for histone H3 lysine9. We identified G9a as a critical factor in the development of murine pancreatic oncogenesis. Overall design: Comparison of gene expression in P48-Cre; KrasG12D and P48-Cre; KrasG12D; G9a flox/flox Pancreas