Crystal structure of human Sirt2 in complex with the peptide-based inhibitor KT9

Crystal structure of human Sirt2 in complex with the peptide-based inhibitor KT9 Descriptor: (2~{S})-2-acetamido-~{N}-[(2~{S},3~{R})-1-azanyl-3-oxidanyl-1-oxidanylidene-butan-2-yl]-6-[[(3~{R})-3-(3,4-dichlorophenyl)sulfanylbutanoyl]amino]hexanamide, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... Authors: Friedrich, F, Schutkowski, M, Einsle, O, Jung, M. Deposit date: 2024-05-17 Release date: 2025-05-28 Last modified: 2025-06-25 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Efficient Crystallization of Apo Sirt2 for Small-Molecule Soaking and Structural Analysis of Ligand Interactions. J.Med.Chem., 68, 2025