Fragment-based discovery of pyrazolopyridones as JAK1 inhibitors with excellent subtype selectivity
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Fragment-based discovery of pyrazolopyridones as JAK1 inhibitors with excellent subtype selectivity Descriptor: 3-methyl-4-phenyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one, Tyrosine-protein kinase JAK2 Authors: Hansen, B.B, Jepsen, T.J, Larsen, M, Sindet, R, Vifian, T, Burhardt, M.N, Larsen, J, Seitzberg, J.G, Carnerup, M.A, Jerre, A, Moelck, C, Rai, S, Nasipireddy, V.R, Ritzen, A. Deposit date: 2019-12-13 Release date: 2020-06-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Fragment-Based Discovery of Pyrazolopyridones as JAK1 Inhibitors with Excellent Subtype Selectivity. J.Med.Chem., 63, 2020
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2019-12-13
