Supplementary Materials: The molecular landscape of premature aging diseases defined by multilayer network exploration

This dataset contains supplementary materials related to study "The molecular landscape of premature aging diseases defined bymultilayer network exploration" (Beust C., Valdeolivas A., Baptista A., Brière G., Ozisik O, Baudot A.) Supplementary Figures:Supplementary Figure S1: Clustering of diseases with 50 iterations of itRWRSupplementary Figure S2: Clustering of diseases with 150 iterations of itRWR Supplementary Tables:Supplementary Table S1:Premature Aging HPO phenotypesSupplementary Table S2: The 67 PA diseases and their 132 associated genes from ORPHANETSupplementary Table S3: Number of nodes, edges, and densities of the 4 network layers composing the multiplexbiological networkSupplementary Table S4: Parameters used for MultiXrank Supplementary Files:Supplementary File S1: Csv file containing the enrichment analysis results computed using the genes associated withphysiological agingSupplementary File S2: Excel file containing the gene nodes belonging to each of the 67 communitiesSupplementary File S3: Excel file containing the gene nodes belonging to each cluster (i.e., the union of the genesbelonging to the set of communities composing the cluster)Supplementary File S4: Csv file containing the diseases belonging to each clusterSupplementary File S5: Excel file containing the enrichment of clusters using lists of physiological aging genesSupplementary File S6: Csv file containing the number of genes differentially expressed in human blood, skin, brain,muscle and breast during aging, from the study of Irizar et al.Supplementary File S7: Excel file containing the enrichment analysis results of the 67 communities, using GO Bio-logical Processes and Cellular Components, and Reactome pathways functional annotationsSupplementary File S8: Excel file containing the enrichment analysis results of the 6 clusters, using GO BiologicalProcesses and Cellular Components, and Reactome pathways functional annotations. The last 2 columns containthe seed nodes of the cluster annotated for the corresponding function and their corresponding diseasesSupplementary File S9: Excel file containing enrichment analysis results of the 6 clusters, using HPO phenotypes