Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C/S240R double mutant bound to DNA and MQ: R273C/S240R-DNA-MQ
收藏Protein Data Bank Japan2024-11-13 更新2026-03-21 收录
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Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C/S240R double mutant bound to DNA and MQ: R273C/S240R-DNA-MQ Descriptor: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ... Authors: Rozenberg, H, Diskin-Posner, Y, Degtjarik, O, Shakked, Z. Deposit date: 2020-12-02 Release date: 2021-12-08 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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2020-12-02
