Isolation by distance promotes gut microbial strain divergence in wild mouse populations

Bacterial species within the mammalian gut microbiota exhibit considerable strain diversity associated with both geography and host genetic ancestry. However, because geography and ancestry are typically confounded, disentangling their contributions to the divergence of gut bacterial strains has remained challenging. Here, we show that isolation by distance (IBD) promotes gut bacterial strain divergence within host species independently of host ancestry. Joint profiling of gut bacterial and mitochondrial genomes from wild-living populations of deer mice (Peromyscus maniculatus) sampled across the United States revealed significant IBD in 27 predominant gut bacterial species, including Muribaculaceae and Lachnospiraceae spp., but limited evidence for co-inheritance of gut bacterial genomes with mitochondria during the diversification of mouse populations. Spore-forming gut bacterial species exhibited reduced IBD, suggesting that adaptations facilitating bacterial dispersal can lessen geo..., , # Data from: Isolation by distance promotes gut microbial strain divergence in wild mouse populations

Dataset DOI: [10.5061/dryad.95x69p8z4](10.5061/dryad.95x69p8z4)

## Description of the data and file structure

Metagenome-assembled genomes from \"Isolation by distance promotes strain diversification in the wild mouse gut microbiota.\"

### Files and variables

#### File: RodentMAGs.tar.gz

**Description:**

This is a compressed archive file that, when opened, contains the RodentMAGs directory. 

Within the RodentMAGs directory, the all_mags directory contains files with the .fa extension. Each .fa file represents a metagenome-assembled genome (MAG) associated with the manuscript titled \"Isolation by distance promotes gut microbial strain divergence in wild mouse populations.

For each .fa file, the prefix preceding the first underscore denotes the sample from which the MAG was derived.

Sample and MAG metadata are provided in TableS1.txt and TableS3.txt, respectively, and are located ..., ,