Inhibiting arginine metabolism via ALDH2/ARG2 axis blockade potentiates immune checkpoint inhibitors in colorectal cancer
收藏NIAID Data Ecosystem2026-05-02 收录
官方服务：
资源简介：
ALDH2/ARG2 Inhibition Enhances CRC Immunotherapy
应用场景：
创建时间：
2025-08-30
相关数据集
Feasibility of Autologous Tumor Cell-TLR9 Agonist Vaccination for Metastatic Colorectal Cancer
Current therapies for metastatic colorectal cancer only prolong life for approximately 2 years. A more innovative therapy that prolongs life significantly or even cures is needed. Bone marrow transpla
NIAID Data Ecosystem50
Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors
Despite overall success, the efficacy of T-cell checkpoint inhibitors is still limited to a minority of cancer patients. Recently, intestinal microbiota was found to critically modulate anti-cancer im
NIAID Data Ecosystem40
DataSheet_1_Good Tumor Response to Chemoradioimmunotherapy in dMMR/MSI-H Advanced Colorectal Cancer: A Case Series.docx
PurposeImmune checkpoint blockade has led to a significant improvement of patient survival in metastatic colorectal cancer (CRC) with DNA mismatch repair-deficiency (dMMR)/microsatellite instability-h
NIAID Data Ecosystem40
Table_1_Hypoxia Correlates With Poor Survival and M2 Macrophage Infiltration in Colorectal Cancer.xlsx
BackgroundIt is widely accepted that the oxygen level in tumor tissue is significantly lower than the adjacent normal tissue, thus termed hypoxia. Intratumoral hypoxia represents a major driving force
NIAID Data Ecosystem50
Efficacy and Safety of Tislelizumab (BGB-A317) as Neo-Adjuvant Treatment in Patients With Colorectal Cancer
This study will evaluate the safety, and tolerability of neo-adjuvant treatment with tislelizumab in participants with early-stage (Stage II-III) Microsatellite Instability-High (MSI-H) or Mismatch Re
NIAID Data Ecosystem40
