co-crystal structure of Lck and aminopyrimidine amide 10b
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co-crystal structure of Lck and aminopyrimidine amide 10b Descriptor: 4-methyl-N~3~-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl)-N~1~-[3-(trifluoromethyl)phenyl]benzene-1,3-dicarboxamide, Proto-oncogene tyrosine-protein kinase LCK Authors: Huang, X. Deposit date: 2008-01-16 Release date: 2008-09-16 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation. J.Med.Chem., 51, 2008
创建时间：
2008-01-16
