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Additional file 2 of Integrated molecular data analysis confirms PDK1 as a candidate risk factor in ALS pathophysiology

NIAID Data Ecosystem2026-05-10 收录

神经退行性机制

分子数据整合分析

数据链接：

https://figshare.com/articles/dataset/Additional_file_2_of_Integrated_molecular_data_analysis_confirms_PDK1_as_a_candidate_risk_factor_in_ALS_pathophysiology/30261848 数据链接链接失效反馈

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资源简介：

Supplementary Material 2

应用场景：

创建时间：

2025-10-01

神经退行性机制

细胞应激通路

Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes are unknown. To investigate these pathw

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AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons. AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons

神经退行性机制

功能障碍研究

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

NIAID Data Ecosystem40

Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology [14 months]

神经退行性机制

胶质细胞功能研究

GRN haploinsufficiency causes frontotemporal lobar degeneration and results in microglial hyperactivation, lysosomal dysfunction and TDP-43 deposition. To understand the contribution of microglial hyp

NIAID Data Ecosystem30

Misconnecting the dots: altered mitochondrial protein-protein interactions and their role in neurodegenerative disorders

蛋白质相互作用

神经退行性机制

Introduction: Mitochondria (mt) are protein-protein interaction (PPI) hubs in the cell where mt-localized and associated proteins interact in a fashion critical for cell fitness. Altered mtPPIs are li

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Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS

神经退行性机制

细胞特异性翻译组

Ubiquitous expression of ALS-causing mutations in superoxide dismutase 1 (SOD1) provoke non-cell autonomous paralytic disease. By combining ribosome affinity purification and high-throughput sequencin

NIAID Data Ecosystem40

Additional file 2 of Integrated molecular data analysis confirms PDK1 as a candidate risk factor in ALS pathophysiology

资源简介：

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