Role of GLI-signaling in the postnatal cardiomyocyte development

Developmentally, we found downregulation of GLI-signaling in adult human CM, adult murine CM, and in late-stage hiPSC-CM. To investigate the role of GLI-signaling in early-stage cardiomyocyte, we inhibited GLI-signaling and undertook bulkRNAseq analysis at two distinct levels of inhibitions. bulkRNAseq analysis at two distinct levels of inhibitions