Crystal structure of DCAF1 in complex with SDIPTAC C8

Crystal structure of DCAF1 in complex with SDIPTAC C8 Descriptor: (4P)-N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-1H-pyrrole-3-carboxamide, (4P,4'P)-5,5'-[(1E,33E)-3,32-dioxo-7,10,13,16,19,22,25,28-octaoxa-4,31-diazatetratriaconta-1,33-diene-1,34-diyl]bis{N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-1H-pyrrole-3-carboxamide}, DDB1- and CUL4-associated factor 1 Authors: Mabanglo, M.F, Srivastava, S, Hoffer, L, Ramnauth, J, Vedadi, M. Deposit date: 2025-12-08 Release date: 2026-05-20 Last modified: 2026-06-10 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Self-Dimerization Induced Proximity Targeting Chimeras (SDIPTAC) Lead to DCAF1 Loss of Function and Inhibition of HIV Replication. J.Med.Chem., 69, 2026