Hypothalamic remodeling of thyroid hormone signaling during hibernation in the arctic ground squirrel

These data were collected from arctic ground
squirrels (Urocitellus parryii) between Summer 2016 and Spring
2019 on a collaborative NSF-funded project examining the
neuroendocrine regulation of the transition between hibernation and
reproduction. The three experiments consist of (1) a repeated
cross-sectional study conducted in both males and females hibernating in
constant darkness and constant temperature (2) an
extreme mid-winter warming study conducted in males only and (3)
an end of hibernation warming study conducted in both males and females
under biologically relevant hibernaculum temperatures.  These
datasets quantify changes in retrograde thyroid hormone signaling between
the pars tuberalis and hypothalamus; ultrastructural changes in
pars tuberalis thyrotrophs, anterior pituitary gonadotrophs, and tanycytic
endfeet at the median eminence; hypothalamic changes in the expression of
nestin and Vimentin, and changes in reproductive parameters
across the hypothalamic-pituitary-gonadal axis.