Comprehensive gene expression analysis using gastric mucosa with autoimmune gastritis

In this study, we aimed to reveal whether gastric mucosa with AIG has a specific gene expression profile, involving in its histology and chronic inflammation. To approach this, we performed comprehensive analysis of gene expression using gastric mucosa with atuoimmune gastritis, that with H. pylori-associated gastritis and healthy mucosa without any inflammation. Potential mechanisms of the gene expression changes in gastric mucosa with AIG were also explored. Biopsy samples were obtained from gastric mucosa with autoimmune gastritis and H. pylori-associated gastritis, and normal mucosa. The samples were put into RNA later and were frozen at -80C for further use. The samples were homogenized and total RNA was extracted.