Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development

NIAID Data Ecosystem2026-03-13 收录

造血调控

基因功能冗余

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE158101 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2022-01-16

SCL establishes a global repressive environment and cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells [ChIP-seq]

造血调控

表观遗传学

Understanding the molecular basis of cell fate decision is critical to shed light onto biological processes supporting tissue formation. In particular, whether lineage-fated cells derive from multi-pr

NIAID Data Ecosystem30

Using single-cell RNA-Seq for unbiased analysis of developmental hierarchies (single cell RNA Seq of Irf8 KO GMP). Mus musculus

单细胞转录组学

造血调控

Single cell RNA seq and bioinformatic analysis is used to characterize myeloid differentiation to uncover novel transcriptional networks and key drivers of hematoipoietic development Overall design: S

NIAID Data Ecosystem20

Identification of genes regulated by Rcor1 in CD71+, TER119- erythroid progenitors using mRNA-seq analysis. Mus musculus

造血调控

转录组差异分析

Transcription cofactor Rcor1 has been linked biochemically both to neurogenesis and hematopoiesis. Here we studied the function of Rcor1 in vivo and showed it is essential to erythropoeisis during emb

NIAID Data Ecosystem20

Duplication and Retention Biases of Essential and Non-Essential Genes Revealed by Systematic Knockdown Analyses

基因功能冗余

基因进化

When a duplicate gene has no apparent loss-of-function phenotype, it is commonly considered that the phenotype has been masked as a result of functional redundancy with the remaining paralog. This is

NIAID Data Ecosystem30

The T-box Transcription Factor Eomesodermin Governs Hemogenic Competence of Yolk Sac Mesodermal Progenitors [scRNA-Seq]

造血调控

单细胞转录组学

Extra-embryonic mesoderm (ExM), the earliest cells that traverse through the primitive streak, give rise to the endothelium as well as hematopoietic progenitors in the developing yolk-sac (YS). How a

NIAID Data Ecosystem20

Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development

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