UGCG transfers glucose to ceramide

Ceramide glucosyltransferase (UGCG, CGT, GCS) catalyzes the first glycosylation step in glycosphingolipid biosynthesis by transferring glucose to ceramide (Ichikawa et al. 1996). UGCG is localized on the cytosolic part of the cis-Golgi membrane. The cytosolic PLEKHA8 (FAPP2) will transport the product GlcCer to the plasma membrane. GlcCer is also transported to the inside of the Golgi membrane by MDR1 ("flipping"; Fabiana de Rosa et al., 2004; Eckford & Sharom, 2005; reviewed by Liu & Li, 2013).

鞘氨醇葡萄糖基转移酶（UGCG、CGT、GCS）催化鞘糖脂生物合成中的首次糖基化步骤，通过将葡萄糖转移至鞘氨醇（Ichikawa 等人，1996年）。UGCG定位于顺式高尔基膜的内质网侧。细胞质中的PLEKHA8（FAPP2）将产物GlcCer转运至质膜。此外，GlcCer亦可通过MDR1（翻转作用；Fabiana de Rosa 等人，2004年；Eckford 与 Sharom，2005年；经 Liu 与 Li，2013年综述）转运至高尔基膜内部。