Extensively Self-Renewing Erythroblasts Derived from Transgenic ß-Yac Mice are a Novel Model System for Studying Globin Switching and Erythroid Maturation

Extensively Self Renewing Erythroblasts (ESREs) are cultured erythroid cells derived from yolk sack or fetal liver. Transcriptome analyses were conducted on ESREs using RNA-seq and compared to published transcriptome analyses of uncultured erythroid cells. Overall design: RNA-seq was conducted on proliferating Extensively Self Renewing Erythroblasts (ESREs) and ESREs after one day of maturation. Biologic duplicates were done at each time point.