Disrupting Mechanotransduction Promotes Regenerative Phenotypes in Human Cells
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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We quantify the effects of FAK inhibition on three-dimensional (3D) cultured human fibroblasts at the cellular and transcriptomic level using single cell RNA-sequencing. We demonstrate that mechanical stress induces pro-fibrotic fibroblast differentiation fates in large organisms, which can effectively be averted by FAK inhibition, which induces discrete fibroblast clusters that promote wound regeneration.
提供机构：
Stanford University
创建时间：
2022-02-20
