Enantioselective Deprotonative Ring Contraction of <i>N</i>1‑Methyl‑<i>N</i>4‑Boc-benzo[<i>e</i>][1,4]diazepine-2,5-diones
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N1-Methyl-N4-Boc-benzo[e][1,4]diazepine-2,5-diones were prepared in good yield and high stereochemical purity from five amino acids. Upon deprotonation, these compounds undergo ring contraction to the corresponding quinolone-2,4-diones with high enantioselectivity, providing efficient entry to a potentially useful drug scaffold. Mechanistic commentary and comparisons to related reactions are provided.
创建时间：
2014-10-03
