Structure of HDAC2 in complex with a macrocyclic inhibitor (compound 25)

Structure of HDAC2 in complex with a macrocyclic inhibitor (compound 25) Descriptor: (1R,3S,6S,18R,27R)-6-(6,6-dihydroxyoctyl)-5,8,18,27,34-pentaazahexacyclo[25.2.2.1~7,10~.1~11,15~.1~14,18~.0~1,3~]tetratriaconta-7,9,11(33),12,14,16-hexaene-4,32-dione (non-preferred name), CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... Authors: Klein, D.J, Yu, W. Deposit date: 2021-05-03 Release date: 2021-07-14 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.543 Å) Cite: Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation. Bioorg.Med.Chem.Lett., 47, 2021