Ranking factors by the effect that normal range variation in their initial values has on model output.

Panel A: The explained variance is defined as the time averaged coefficient of variation for thrombin for a given factor expressed as a fraction of the sum of all the time averaged coefficients of variation for thrombin for the 8 factors. Panel B: For a given factor, the effect of varying its level across its normal range on all model species is defined as the mean of the time averaged coefficient of variations for all 34 species. The explained variance is then defined as fraction of the sum of the mean time averaged coefficients of variation for the 8 factors (Figures S2 and S3).