Crystal structure of PDE4D catalytic domain complexed with compound 23a
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Crystal structure of PDE4D catalytic domain complexed with compound 23a Descriptor: (2~{R},4~{S})-6-ethyl-2-[(2~{E})-2-hydroxyiminoethyl]-2,8-dimethyl-4-(2-methylprop-1-enyl)-3,4-dihydropyrano[3,2-c][1,8]naphthyridin-5-one, Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ... Authors: Huang, Y.-Y, Luo, H.-B. Deposit date: 2022-03-21 Release date: 2022-07-06 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.100009 Å) Cite: Structure-based optimization of Toddacoumalone as highly potent and selective PDE4 inhibitors with anti-inflammatory effects. Biochem Pharmacol, 202, 2022
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2022-03-21
