Integrated single-cell transcriptomic atlas of human tricuspid and aortic valve diseases

This dataset contains processed single-cell RNA sequencing (scRNA-seq) data from human tricuspid valve (TV) and aortic valve (AV) leaflets, including samples from tricuspid regurgitation (TR), calcific aortic valve disease (CAVD), and corresponding controls. The dataset includes expression matrices, cell type annotations, and metadata. Data were integrated and analyzed to characterize cellular composition, transcriptional programs, and intercellular interactions across valve types and disease conditions. Original datasets were obtained from publicly available sources (HRA010091 and PRJNA562645). This resource is intended to facilitate further investigation into valvular biology and disease-associated transcriptional changes.