Reaction Discovery Employing Macrocycles: Transannular Cyclizations of Macrocyclic Bis-lactams
收藏NIAID Data Ecosystem2026-03-06 收录
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Macrocyclic bis-lactams have been synthesized by cyclodimerization of homoallylic amino esters employing a Zr(IV)-catalyzed ester-amide exchange protocol. Base-mediated transannular cyclizations have been identified to access both bicyclic [5-11] and tricyclic [5-8-5] frameworks in good yield and diastereoselectivity. Preliminary mechanistic studies support an olefin isomerization−intramolecular conjugate addition pathway.
创建时间：
2009-01-15
