FKBP51 in complex with tricyclic ligands
收藏ESRF Portal2024-01-01 更新2026-04-23 收录
下载链接：
https://doi.esrf.fr/10.15151/ESRF-DC-1602472053
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资源简介：
FK506-binding proteins hold high potential as drug targets but the scope of usable scaffolds for the generation of high affinity ligands is limited. Here we used structure-based optimization to discover tricyclic FKBP ligands with picomolar biochemical and subnanomolar cellular activity that represent the most potent FKBP ligands known to date.
创建时间：
2024-01-01
