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Stereoselective Synthesis of Fluorinated 2,3-Dihydroquinolin-4(1H)-ones via a One-Pot Multistep Transformation

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Figshare2016-02-22 更新2026-04-29 收录
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A new organocatalytic one-pot multistep transformation via Knoevenagel condensation/aza-Michael addition/electrophilic fluorination has been developed. Simple starting materials were used under mild conditions to construct fluorinated 2,3-dihydroquinolin-4­(1H)-one derivatives in good to high yields (up to 98%) and diastereoselectivities (dr up to 99/1).

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2016-02-22
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