Gene expression of S100A10 knocked down human breast cancer cells. Gene expression of S100A10 knocked down human breast cancer cells

The expression level of S100A10 was much higher in the CD44+ cancer cells metastasized to the liver than those at the primary site in the breast cancer patient-derived tumor xenograft mice. Expression level of S100A10 increased by the oncoprotein, PML/RARα and RAS, and its higher expression is linked to worse outcome in a number of cancer types including breast cancers Overall design: Human breast cancer MDA-MB-231 cells were infected with lentivirus encoding shRNA sequences against S100A10. Two different shRNA sequences (shS100A10-1, shS100A10-5) that effectively knockdown S100A10 were used. Analyses were duplicated.