Enrichment analysis of biomarker-based patient clusters: A qualitative view.

The NHANES code and description of validated terms found in clusters generated by pre-processing with the Z-score normalization method and clustering algorithm with three algorithms (CLICK, K-means and SOM) (top) or using the CLICK clustering algorithm with four pre-processing procedures (bottom). Raw = no transformation; Norm = transformation to normal; Z-score normalization or Z-score normalization with age-adjustment). All the marked terms were enriched significantly (hyper geometric test, P value<0.05) in both the training and validation sets.