STUDY ON EFFECTS OF PROBIOTICS ON WHOLE GUT MICROBIOME AND CLINICAL COURSE IN PATIENTS WITH CRITICAL CARE ILLNESSES

Ventilator Associated Pneumonia (VAP) is thought to be secondary to bacterial colonization of the upper digestive tract and aspiration of contaminated secretions into lower airway. Probiotics are postulated to prevent colonization of these pathogenic bacteria. In this prospective observational study, we aimed to investigate the effects of probiotics on gut microbiota and its relation with clinical outcomes in mechanically ventilated patients.