Lysine 117 residue is essential for the function of the hepatocyte nuclear factor 1α in pancreas. Lysine 117 residue is essential for the function of the hepatocyte nuclear factor 1α in pancreas

To determine the impact of K117E mutation on HNF1α functions, we generated a C57BL/6J knock-in mouse model wherein the lysine 117 (K117) was replaced with glutamic acid (E117) in the endogenous murine HNF1α locus by CRISPR/Cas9. We then performed gene expression profiling analysis using data obtained from RNA-seq of pancreas of WT and HNF1αK1117E Hom mice of 9 weeks old (n=3/group) Overall design: Comparative gene expression profiling analysis of RNA-seq data for pancreas of WT and HNF1αK1117E Hom mice of 9 weeks old (n=3/group).