Vaccine induced immune cell subsets in PBMC samples (Note: 2V - First MVA, 2V+1wk—one week after first MVA vaccination, 3V - Last MVA booster dose, 3V+1wk—one week after final MVA booster dose, 3V+2wk—two weeks after final MVA dose, 3V+48wk—48 weeks after final MVA booster).

(3A) Frequency of vaccine induced circulating T follicular helper cells in Groups A and B after 2nd vaccination, 1-week post 2nd vaccination, 3rd vaccination, and 1st week, 2nd week, and 48th week post 3rd vaccination. (3B) Frequency of Plasma B cells in Groups A and B after 2nd vaccination, 1st week post 2nd vaccination, 3rd vaccination, 1st week, 2nd week and 48 weeks post 3rd vaccination (3C) Frequency of Circulating Regulatory cells T cells in Groups A and B after 2nd vaccination, 1st week post 2nd vaccination, 3rd vaccination, 1st week, 2nd week and 48 weeks post 3rd vaccination. Graphical representation of the frequency of immune cells in placebo and vaccinees of both groups at different time points. Horizontal bars represent mean values and P values were calculated using two-way ANOVA using Bonferroni post hoc test.